Severe systemic BCG infection or reaction may occur,including BCG sepsis,granulomatous pulmonary or hepatic reactions,abscesses(skin,renal or psoas)infected aneurysms,infection of implants or surrounding tissues(e.g aortic graft,cardiac defibrillator,hip or knee arthroplasty),Reiter’s syndrome,chorioretinitis,conjunctivitis,uveitis,haemophagocytic syndrome,as well as complications due to missed or delayed diagnosis,bladder contracture,and reduced or absent sperm count(oligospermia, azoospermia)