Patients ages 30 to 74 who took atypical antipsychotics such as risperidone (sold as Risperdal), quetiapine (Seroquel), olanzapine (Zyprexa) and clozapine (Clozaril) had a significantly higher risk of sudden death from cardiac arrhythmias and other cardiac causes than patients who did not take these medications, according to a new study funded by the Department of Health & Human Services' (HHS) Agency for Healthcare Research and Quality (AHRQ). The risk of death increased with higher doses of the drugs taken.

Background Attacks of wheezing induced by upper respiratory viral infections are common in preschool children between the ages of 10 months and 6 years. A short course of oral prednisolone is widely used to treat preschool children with wheezing who present to a hospital, but there is conflicting evidence regarding its efficacy in this age group.

نشرت مجلة ذا لانست الطبية أنه بسبب كثرة الجدل الحاصل حول ما إذا كان الجيل الثاني من الأدوية المضادة للهذيان أفضل من الجيل الأول ، فقد تم عمل تجارب عشوائية محكومة لمقارنة آثار هذين الجيلين من الأدوية للمرضى الذين يعانون من انفصام الشخصية.

وقد اشتملت الدراسة على 150 تجربة مزدوجة مقفلة ومعظمها على المدى القصير تضمنت 21533 مشارك. حيث تم استبعاد الدراسات المفتوحة لأنها من ناحية التصنيف تفضل استخدام الجيل الثاني من هذه الأدوية. وقد لوحظ أن أربعة من أدوية الجيل الثاني المضادة للهذيان كانت أفضل من الجيل الأول لفعاليتها الشاملة.

Objective To systematically review the efficacy of steroids in the prevention of acute respiratory distress syndrome (ARDS) in critically ill adults, and treatment for established ARDS.

Background Although virus-induced wheezing is common in preschool-age children, optimal management remains elusive. We examined the efficacy and safety of preemptive treatment with high-dose fluticasone in reducing the severity of recurrent virus-induced wheezing in children.

Green tea may negate the effects of Takeda Pharmaceutical Co. ’s cancer medicine Velcade, researchers found, contrasting with studies that show the anti-cancer properties of green-tea products.

Low levels of vitamin D increase the risk of cognitive impairment in the elderly, according to findings from the nationally representative, population-based Health Survey for England 2000.

Background: It is unclear whether the use of selective serotonin reuptake inhibitors (SSRIs) and other antidepressant drugs reduce the risk of suicide in people with depression. We explored the association between exposure to SSRIs and risk of suicide completion or attempt.

Methods: We conducted a systematic review of observational studies that reported completed or attempted suicide in depressed individuals who were exposed to SSRIs compared with those who were not exposed to antidepressants. We assessed the overall risk of completed or attempted suicide.

Background: Use of proton-pump inhibitors in the management of peptic ulcer bleeding is controversial because of discrepant results reported in different ethnic groups.

Objective: To determine whether intravenous esomeprazole better prevents recurrent peptic ulcer bleeding than placebo in a multiethnic patient sample.

Design: Randomized trial conducted between October 2005 and December 2007; patients, providers, and researchers were blinded to group assignment.

أصدرت إدارة الغذاء والدواء الأمريكية FDA تقريراً خاصاً بالصحة العامة لتنبيه المستهلكين، والمرضى، والعاملين في الرعاية الصحية ، ومقدمي الرعاية الصحية عن احتمال حدوث أعراض جانبية خطيرة ومهددة للحياة بسبب الاستخدام غير الصحيح للأدوية الجلدية المستخدمة للتخدير الموضعي,والتي تعرف باسم الأدوية المخدرة الموضعية.