General health

Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily

2006-07-10

Journal of American Medical Association (JAMA) published in edition 296 in 2006

Context: During a clinical trial of a novel hydrocodone/acetaminophen (Paracetamol) combination, a high incidence of serum alanine aminotransferase (ALT) elevations was observed.

Objective: To characterize the incidence and magnitude of ALT elevations in healthy participants receiving 4 g of acetaminophen daily, either alone or in combination with selected opioids, as compared with participants treated with placebo.

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New Warnings to Avastin

2006-11-01

FDA and Genentech, Inc, have notified healthcare professionals regarding safety labeling revisions for bevacizumab injection (Avastin) that warn of potential risks for reversible posterior leukoencephalopathy syndrome (RPLS) and nasal septum perforation associated with its use.

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Combined Use of 5-Hydroxytryptamine Receptor Agonists (Triptans), Selective Serotonin Reuptake Inhibitors (SSRIs) or Selective Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs) May Result in Life-threatening Serotonin Syndrome

The FDA has important new safety information about taking triptans (drugs used to treat migraine headaches) together with certain types of antidepressant medicines. The antidepressant medicines of concern are selective serotonin reuptake inhibitors (SSRIs) and selective serotonin/norepinephrine reuptake inhibitors (SNRIs).

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تناول دواء لاموتريجين (Lamtrigine®) خلال فترة الحمل الأولى

2006-10-08

أبلغت إدارة الغذاء والدواء الأمريكية مقدمي الرعاية الصحية حسب المعلومات الأولية الواردة من هيئة تسجيل أدوية الصرع والحمل في شمال أمريكا(North American Antiepileptic Drug Pregnancy Registry NAAED) أن تعرض الجنين لدواء لاموتريجين (Lamotrigine) خلال الثلاثة الشهور الاولى من الحمل قد يرتبط بارتفاع نسبة أحتمال الإصابة بالحنك المشقوق أو الشفة المشقوقة (Cleft lip or Palate ) في الاطفال الحديثي الولادة .

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Effectiveness Of Certain Antidepressants May Be Influenced By Gene Variations Of Individuals

2006-11-11

Whether specific types of antidepressants are effective for patients with late-life major depression may depend if they have certain genetic variations, according to a study in the October 4 issue of JAMA.

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Ibuprofen and Aspirin Taken Togethe

2006-11-13

FDA notified consumers and healthcare professionals that taking Ibuprofen for pain relief and aspirin at the same time may interfere with the benefits of aspirin taken for the heart. Ibuprofen can interfere with the anti-platelet effect of low dose aspirin (81 mg per day), that may render aspirin less effective when used for cardioprotection and stroke prevention. Although it is all right to use Ibuprofen and aspirin together.

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Tamiflu (oseltamivir phosphate)

2006-11-25

Audience: Pediatric and primary care healthcare professionals and patients

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Treatment Options for Nausea and Vomiting During Pregnancy

2006-11-26

Nausea and vomiting, common symptoms during pregnancy often are regarded as an unpleasant but normal part of pregnancy during the first and early second trimesters. Nausea and vomiting of pregnancy (NVP) occurs in approximately 75-80% of pregnant women. The exact etiology and pathogenesis of NVP are poorly understood and are most likely multifactorial. Some theories for the etiology of NVP are psychological predisposition, evolutionary adaptation, hormonal stimuli, and Helicobacter pylori infection.

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Interaction between Warfarin and Cranberry Juice

2006-11-27

Warfarin is extensively used for anticoagulation to a target international normalized ratio of 2.0-3.0 for most indications or 2.5-3.5 for high-risk indications; however, many drugs and dietary supplements induce fluctuations in the international normalized ratio. Such fluctuations may lead to therapeutic failure or bleeding complications. Cranberry juice is increasingly used for the prevention and adjunctive treatment of urinary tract infections.

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High-dose corticosteroid exposure and osteoporosis intervention in adults

2006-11-29

Background: High-dose corticosteroid exposure is associated with increased risk of bone loss and osteoporotic fractures.

Objective: To examine high-dose corticosteroid use and osteoporosis screening and treatment trends in patients receiving high-dose oral or inhaled corticosteroids in a large managed care organization.

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